Triethyl phosphite → HCID 86605753, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (4-chloromethyl-1,3-thiazol-2-yl)methyl benzoate (6.4 g), triethyl phosphite (8.7 g) was stirred at 150° C. for 17 hrs. Excess triethyl phosphite was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (1:2, v/v)-ethyl acetate to give {4-[(diethoxyphosphoryl)methyl]-1,3-thiazol-2-yl}methyl benzoate as a yellow oil (8.0 g, yield 91%).

Provenance & Evidence