Hydrochloric Acid → HCID 178525239, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4-{(E)-2-[3-(methoxymethoxy)-1-phenyl-1H-pyrazol-4-yl]ethenyl}-1,3-thiazol-2-yl)methyl benzoate (1.02 g) in methanol (30 mL) was added concentrated hydrochloric acid (0.28 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hrs. The reaction mixture was evaporated under reduced pressure, and the residue was washed with ethyl acetate-methanol to give {4-[(E)-2-(3-hydroxy-1-phenyl-1H-pyrazol-4-yl)ethenyl]-1,3-thiazol-2-yl}methyl benzoate (0.79 g, yield 79%) as colorless crystals. melting point: 215-216° C.

Provenance & Evidence