Triethyl phosphite → HCID 86605756, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 4-(4-chloromethyl-5-methyl-1,3-thiazol-2-yl)piperazine-1-carboxylate (2.91 g) and triethyl phosphite (3.20 g) was stirred at 160° C. for 15 hrs. Excess triethyl phosphite was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (1:2-4:1, v/v) to give tert-butyl 4-{4-[(diethoxyphosphoryl)methyl]-5-methyl-1,3-thiazol-2-yl}piperazine-1-carboxylate as a yellow oil (2.20 g, yield 58%).

Provenance & Evidence