Sodium sulfate decahydrate → HCID 69217757, compound

Participants

Reaction Steps

To a solution of ethyl 1-benzyl-3-({3-methoxy-4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyl}oxy)-1H-pyrazole-4-carboxylate (0.90 g) in tetrahydrofuran (30 mL) was added lithium aluminum hydride (0.06 g) at 0° C. and the mixture was stirred at room temperature for 3 hrs. Sodium sulfate decahydrate (0.51 g) was added to the reaction mixture, and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with ethyl acetate, the precipitate was filtered off and the filtrate was concentrated. The obtained crystals were collected by filtration to give [1-benzyl-3-({3-methoxy-4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyl}oxy)-1H-pyrazol-4-yl]methanol (0.63 g, yield 77%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 90-91° C.

Provenance & Evidence