HCID 69218590, compound → HCID 86605772, compound

Participants

Reaction Steps

A mixture of {1-benzyl-3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methylbenzyl)oxy]-1H-pyrazol-4-yl}methanol (0.27 g), activated manganese dioxide (0.90 g) and tetrahydrofuran (20 mL) was stirred at room temperature for 3 hrs. Manganese dioxide was removed by filtration and the filtrate was concentrated. The obtained crystals were collected by filtration to give 1-benzyl-3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methylbenzyl)oxy]-1H-pyrazole-4-carbaldehyde as colorless crystals (0.22 g, yield 81%). Recrystallization from ethyl acetate-hexane gave colorless needle crystals. melting point: 121-122° C.

Provenance & Evidence