Tetraethyltin → HCID 69216272, compound

Participants

Reaction Steps

Ethyl 1-benzyl-3-[(3-bromo-4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)oxy]-1H-pyrazole-4-carboxylate (2.07 g), tetraethyltin (2.07 g), tetrakis(triphenylphosphine)palladium (0.40 g) and toluene (50 mL) was stirred under an argon atmosphere while heating under reflux for 3 days. After concentration of the reaction mixture, the residue was subjected to silica gel column chromatography to give ethyl 1-benzyl-3-[(3-ethyl-4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)oxy]-1H-pyrazole-4-carboxylate as colorless crystals (0.96 g, 51%) from a fraction eluted with ethyl acetate-hexane (1:2, v/v). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 125-126° C.

Provenance & Evidence