HCID 69215618, compound → HCID 86605774, compound

Participants

Reaction Steps

A mixture of {1-benzyl-3-[(3-ethyl-4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)oxy]-1H-pyrazol-4-yl}methanol (0.23 g), activated manganese dioxide (0.70 g) and tetrahydrofuran (10 mL) was stirred at room temperature for 3 hrs. Manganese dioxide was removed by filtration and the filtrate was concentrated. The obtained crystals were collected by filtration to give 1-benzyl-3-[(3-ethyl-4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)oxy]-1H-pyrazole-4-carbaldehyde as colorless crystals (0.20 g, yield 87%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 128-129° C.

Provenance & Evidence