Acetic Acid → HCID 58944562, compound

Participants

Reaction Steps

A solution of N-(2,4-dimethoxybenzyl)-7-[(4aS,6R,7aS)-2-(4-methoxyphenyl)-hexahydrocyclopenta[d][1,3]dioxin-6-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (123 mg, 0.238 mmol, prepared following the procedure described in Example 1a-f using 2,4-dimethoxybenzylamine in step c) and AcOH (1.00 mL, 17.6 mmol) in water (0.500 mL) and THF (0.500 mL) were stirred at rt overnight. The reaction mixture was concentrated in vacuo and purification by silica gel chromatography eluting with a gradient of 0 to 10% MeOH in DCM afforded the title compound (43.0 mg, 73%). LC/MS: Rt=0.15 min, ES+ 249 (FA standard).

Provenance & Evidence