Hydrochloric Acid → HCID 86605790, compound

Participants

Reaction Steps

To a mixture of 3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazole-4-carbaldehyde (28.0 g), tetraethyl methylenediphosphonate (17.5 g) and N,N-dimethylformamide (300 mL) was added sodium hydride (60% in oil, 2.43 g) at 0° C. The mixture was stirred at room temperature for 2 hrs. The reaction mixture was poured into water, 2N hydrochloric acid was added to acidify the solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography and eluted with acetone-hexane (2:3, v/v) to give diethyl (Z)-2-(3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazol-4-yl}ethenylphosphonate as a colorless oil (1.94 g, yield 5%).

Provenance & Evidence