Sodium Sulfite → HCID 86605797, compound

Participants

Reaction Steps

To a mixture of 2-(2-furyl)-4-({2-methoxy-4-[({4-[(Z)-2-(methylsulfinyl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]phenoxy}methyl)-5-methyl-1,3-oxazole (0.20 g) and tetrahydrofuran (20 mL) was added m-chloroperbenzoic acid (0.08 g) at room temperature, and the mixture was stirred at the same temperature for 1 hr. Saturated aqueous sodium sulfite solution was added to the reaction mixture, and the mixture was stirred at room temperature for 10 min, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-hexane (1:1, v/v) to give 2-(2-furyl)-4-({2-methoxy-4-[({4-[(Z)-2-(methylsulfonyl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]phenoxy}methyl)-5-methyl-1,3-oxazole as colorless crystals (0.15 g, yield 71%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 158-159° C.

Provenance & Evidence