Hydrochloric Acid → HCID 86605812, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of methyl 5-[({4-[(E)-2-(diethoxyphosphoryl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]-2-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzoate (0.40 g), tetrahydrofuran (2 mL) and ethanol (2 mL) was added 1N aqueous sodium hydroxide solution (1 mL), and the mixture was stirred at 50° C. for 1 hr. 1N Hydrochloric acid (1 mL) and water were added to the reaction mixture, and the precipitated crystals were collected by filtration to give 5-[({4-[(E)-2-(diethoxyphosphoryl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]-2-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzoic acid as colorless crystals (0.29 g, yield 74%). Recrystallization from tetrahydrofuran-hexane gave colorless prism crystals. melting point: 169-170° C.

Provenance & Evidence