反应详情

To a mixture of ethyl 2-((E)-2-{3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazol-4-yl}ethenyl)-1,3-thiazole-4-carboxylate (0.13 g), tetrahydrofuran (1 mL) and ethanol (1 mL) was added 1N aqueous sodium hydroxide solution (1 mL), and the mixture was heated under reflux for 1 hr. To the reaction mixture were added 1N hydrochloric acid (1 mL) and water, and the precipitated crystals were collected by filtration to give 2-((E)-2-{3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazol-4-yl}ethenyl)-1,3-thiazole-4-carboxylic acid as yellow crystals (0.08 g, yield 67%). Recrystallization from tetrahydrofuran-hexane gave yellow prism crystals. melting point: 170-172° C.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1 hr
3. filtrationthe precipitated crystals were collected by filtration