Hydrochloric Acid → HCID 86605838, compound

Participants

Reaction Steps

To a mixture of methyl 4-[4-({4-[({4-[(E)-2-(diethoxyphosphoryl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]-2-methoxyphenoxy}methyl)-5-methyl-1,3-oxazol-2-yl]benzoate (0.34 g), tetrahydrofuran (5 mL) and methanol (5 mL) was added 1N aqueous sodium hydroxide solution (2 mL), and the mixture was heated under reflux for 1 hr. To the reaction mixture were added 1N hydrochloric acid (2 mL) and water, and tetrahydrofuran and methanol were evaporated under reduced pressure. The precipitated crystals were collected by filtration to give 4-[4-({4-[({4-[(E)-2-(diethoxyphosphoryl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]-2-methoxyphenoxy}methyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid as colorless crystals (0.31 g, yield 94%). Recrystallization from tetrahydrofuran-hexane gave colorless prism crystals. melting point: 194-195° C.

Provenance & Evidence