Cornforth reagent → HCID 66617615, compound

Participants

Reaction Steps

(1S,5S)-5-({[tert-Butyl(diphenyl)silyl]oxy}methyl)cyclopent-2-en-1-ol (460. mg, 1.30 mmol) was dissolved in DCM (15.0 mL) and pyridinium dichromate (1.47 g, 3.91 mmol) was added. The mixture was stirred at rt overnight, at which point LC/MS indicated complete conversion. The mixture was diluted with DCM (15.0 mL), filtered and concentrated in vacuo. Silica gel chromatography eluting with 0 to 50% EtOAc in hexanes afforded the title compound (400. mg, 79%). LC/MS: Rt=2.42 min, ES+ 351 (AA standard).

Provenance & Evidence