Hydrochloric Acid → HCID 86605866, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-{4-[(4-{[(4-formyl-1-phenyl-1H-pyrazol-3-yl)oxy]methyl}-2-methoxyphenoxy)methyl]-5-ethyl-1,3-oxazol-2-yl}phenyl methanesulfonate (0.20 g), tetrahydrofuran (2 mL) and ethanol (2 mL) was added 1N aqueous sodium hydroxide solution (2 mL), and the mixture was stirred at 60° C. for 1 hr. To the reaction mixture was added dilute hydrochloric acid to acidify the solution, and the precipitated crystals were collected by filtration to give 3-[(4-{[2-(3-hydroxyphenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-1-phenyl-1H-pyrazole-4-carbaldehyde as colorless crystals (0.10 g, yield 59%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 193-194° C.

Provenance & Evidence