N-Iodosuccinimide → HCID 58944673, compound

Participants

Reaction Steps

To a solution of 7-[(4aS,6R,7aS)-2-(4-methoxyphenyl)hexahydrocyclopenta[d]-[1,3]dioxin-6-yl]-4-methyl-7H-pyrrolo[2,3-d]pyrimidine (363 mg, 0.995 mmol, as prepared in Example 1a-f) in DCM (15.0 mL) was added N-iodosuccinimide (256 mg, 1.14 mmol), and the mixture was stirred at rt overnight. Silica gel chromatography eluting with a gradient of 25 to 100% EtOAc in hexanes afforded the title compound (253 mg, 52%). LC/MS: Rt=2.03 min, ES+ 492 (AA standard).

Provenance & Evidence