Sodium sulfate decahydrate → HCID 69217132, compound

Participants

Reaction Steps

To a solution of ethyl 4-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-2-phenylpyrimidine-5-carboxylate (3.40 g) in tetrahydrofuran (100 mL) was added lithium aluminum hydride (0.24 g) at room temperature, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with ethyl acetate (100 mL), and sodium sulfate decahydrate (2.0 g) was further added. After removing the precipitate by filtration, the filtrate was concentrated. The obtained crystals were recrystallized from ethyl acetate to give {4-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-2-phenylpyrimidin-5-yl}methanol as colorless prism crystals (2.20 g, yield 70%). melting point: 150-151° C.

Provenance & Evidence