Sodium sulfate decahydrate → HCID 69217738, compound

Participants

Reaction Steps

To a solution of ethyl (2E)-3-{3-({3-methoxy-4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyl}oxy)-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}-2-propenoate (0.507 g) in tetrahydrofuran (50 mL) was added diisobutylaluminum hydride (0.95 M hexane solution, 7.0 mL) at room temperature, and the mixture was stirred at room temperature for 1 hr. Sodium sulfate decahydrate (2.14 g) was added to the reaction mixture, and the mixture was further stirred for 2 hrs. After removing the precipitate by filtration, the filtrate was concentrated. The residue was subjected to silica gel column chromatography to give (2E)-3-{3-({3-methoxy-4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyl}oxy)-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}-2-propen-1-ol as colorless crystals from a fraction eluted with tetrahydrofuran-hexane (1:1, v/v). Recrystallization from ethyl acetate-hexane gave colorless powder (0.300 g, yield 63%). melting point: 118-119° C.

Provenance & Evidence