Hydrochloric Acid → HCID 69216116, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of ethyl 4-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-2-phenylpyrimidine-5-carboxylate (0.47 g), tetrahydrofuran (10 mL) and ethanol (10 mL) was added 1N aqueous sodium hydroxide solution (3 mL), and the mixture was stirred at 60° C. for 1 hr. The reaction mixture was poured into water, 2N hydrochloric acid was added to acidify the solution, and the precipitated crystals were collected by filtration. Recrystallized from methanol-ethyl acetate gave 4-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-3-methoxybenzyl)oxy]-2-phenylpyrimidine-5-carboxylic acid as pale-yellow needle crystals (0.18 g, yield 40%). melting point: 163-164° C.

Provenance & Evidence