Hydrochloric Acid → HCID 69213994, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of ethyl (2E)-3-[4-({4-[({4-[(E)-2-(2-ethyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]-2-methoxyphenoxy}methyl)-5-methyl-1,3-oxazol-2-yl]-2-propenoate (0.25 g), tetrahydrofuran (2 mL) and ethanol (2 mL) was added 1N aqueous sodium hydroxide solution (2 mL), and the mixture was stirred at 50° C. for 2 hrs. 1N hydrochloric acid and water were added to the reaction mixture to acidify the solution, and the precipitated crystals were collected by filtration to give (2E)-3-[4-({4-[({4-[(E)-2-(2-ethyl-1,3-thiazol-4-yl)ethenyl]-1-phenyl-1H-pyrazol-3-yl}oxy)methyl]-2-methoxyphenoxy}methyl)-5-methyl-1,3-oxazol-2-yl]-2-propenoic acid as colorless crystals (0.21 g, yield 88%). Recrystallization from acetone-hexane gave colorless prism crystals. melting point: 125-126° C.

Provenance & Evidence