Hydrochloric Acid → HCID 67549831, compound

Participants

Reaction Steps

A solution of 2-hydroxymethyl-3-methyl-3H-imidazole-4-carboxylic acid methyl ester (250 mg, 1.5 mmol) in ethyl acetate/methanol 6 ml, 1:1) was converted to the hydrochloride by usage of an excess of an etheral solution of hydrogen chloride. After evaporation, the light brown residue was treated with thionyl chloride (1.1 ml, 15 mmol) and stirred for 0.5 h. After evaporation, the title compound was obtained as brown solid (100% yield). MS: m/e=189(M+H+), mp 106-108° C.

Provenance & Evidence