HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Methoxy-4-nitro-phenyl)-4-pyrrolidin-1-yl-piperidine → 2-Methoxy-4-(4-(pyrrolidin-1-yl)piperidin-1-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Methoxy-4-nitro-phenyl)-4-pyrrolidin-1-yl-piperidine | HCID 57416147 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methoxy-4-(4-(pyrrolidin-1-yl)piperidin-1-yl)aniline | HCID 57416146 | — |
Reaction Steps
321 mg (1.053 mmol) 1-(3-methoxy-4-nitro-phenyl)-4-pyrrolidin-1-yl-piperidine are dissolved in 10 ml THF, combined with 30 mg Raney nickel and then shaken for 9 days at 20° C. under 4 bar hydrogen atmosphere. The catalyst is filtered off and washed again with THF. The solvent is eliminated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371753B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-839d56d415754bd09741174d660d841d |
| Source note | uspto-grants-2008_05 |