HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → Morpholine-4-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | 7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine | HCID 59711805 | — |
| Reactant | (4-Methoxy-7-phenyl-benzothiazol-2-yl)-carbamic acid benzyl ester | HCID 86584926 | — |
| Product | Morpholine-4-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amide | HCID 11326842 | — |
Reaction Steps
7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine was first reacted with phenyl chloroformate as described for (4-methoxy-7-phenyl-benzothiazol-2-yl)-carbamic acid benzyl ester in WO01/97786 and then with morpholine. Usual workup, peparative reversed-phase HPLC and final dry-freezing afforded the title compound as light brown powder. MS: m/e=394(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371748B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-dfda485f9e2c490986edb32e52098f60 |
| Source note | uspto-grants-2008_05 |