Phenyl chloroformate → HCID 11361740, compound

HRID 2222155Notes

Reaction equation

HRID 2222155 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.Cl[C:20](OC1C=CC=CC=1)=[O:21].[OH:29][C:30]1([CH3:36])[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:20]([N:33]3[CH2:34][CH2:35][C:30]([OH:29])([CH3:36])[CH2:31][CH2:32]3)=[O:21])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 15891Phenyl chloroformateHCID 156491744-Methylpiperidin-4-olHCID 220157354-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine

Product 1

HCID 11361740HCID 11361740, compound

Procedure

Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine, phenyl chloroformate and 4-hydroxy-4-methyl-piperidine, the title compound was prepared as off-white solid (56% yield). MS: m/e=406(M+H+), mp 90-95° C.

Sources & evidence

ORD record
ord-84e9f64a4d064d0dbec558907283717f
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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