HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Azabicyclo(2.2.2)octane → 2-Aza-bicyclo[2.2.2]octane-2-carboxylic acid [4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Azabicyclo(2.2.2)octane | HCID 9236 | — |
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | 4-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine | HCID 22015735 | — |
| Product | 2-Aza-bicyclo[2.2.2]octane-2-carboxylic acid [4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-amide | HCID 11384069 | — |
Reaction Steps
Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine, phenyl chloroformate and 2-aza-bicyclo[2.2.2]octane, the title compound was prepared as off-white crystals (53% yield). MS: m/e=402(M+H+), mp 237-239° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371748B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-0de5a3b0151c44e7b1a777f62343ef92 |
| Source note | uspto-grants-2008_05 |