HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 2-[(2-Methoxy-ethylamino)-methyl]-N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 2-Chloromethyl-N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-isonicotinamide | HCID 22719561 | — |
| Product | 2-[(2-Methoxy-ethylamino)-methyl]-N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-isonicotinamide | HCID 11751456 | — |
Reaction Steps
The title compound was prepared from 2-chloromethyl-N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-isonicotinamide and 2-methoxy-ethylamine in the same manner as described for N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-2-morpholin-4-ylmethyl-isonicotinarmide and afforded as yellow solid (60% yield). MS: m/e=457(M+H+), mp 93-95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371748B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-931f2e4fc5ba4b6c9eb2f0480f08f899 |
| Source note | uspto-grants-2008_05 |