4-(Chloromethyl)benzoic acid → 4-Chloromethyl-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-benzamide

HRID 2222164Notes

Reaction equation

HRID 2222164 reaction equation
[O:1]1[CH2:7][CH:6]([C:8]2[C:16]3[S:15][C:14]([NH2:17])=[N:13][C:12]=3[C:11]([O:18][CH3:19])=[CH:10][CH:9]=2)[CH2:5][O:4][CH2:3][CH2:2]1.[Cl:20][CH2:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=1.O1CC(C2C3SC(NC(C4SC(C)=CC=4)=O)=NC=3C(OC)=CC=2)COCC1>>[Cl:20][CH2:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH:17][C:14]2[S:15][C:16]3[C:8]([CH:6]4[CH2:5][O:4][CH2:3][CH2:2][O:1][CH2:7]4)=[CH:9][CH:10]=[C:11]([O:18][CH3:19])[C:12]=3[N:13]=2)=[O:27])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 742344-(Chloromethyl)benzoic acidHCID 113731005-Methyl-thiophene-2-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amideHCID 597118057-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 117508444-Chloromethyl-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-benzamide

Procedure

Using 7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine and 4-chloromethyl-benzoic acid, the title compound was prepared in the same manner as described for 5-methyl-thiophene-2-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amide and obtained as light brown powder. MS: m/e=434(M+H+).

Workup

  1. customobtained as light brown powder

Sources & evidence

ORD record
ord-01cb9a7247c4447581001e81591105b2
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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