HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methoxyethyl)(methyl)amine → N-(7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-2-pyrrolidin-1-ylmethyl-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methoxyethyl)(methyl)amine | HCID 300977 | — |
| Reactant | 2-{[(2-Methoxy-ethyl)-methyl-amino]-methyl}-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide | HCID 22993416 | — |
| Reactant | 2-Chloromethyl-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide | HCID 86595146 | — |
| Product | N-(7-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-2-pyrrolidin-1-ylmethyl-isonicotinamide | HCID 86595150 | 48% |
Reaction Steps
2-Chloromethyl-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide and N-(2-methoxyethyl)-methylamine were reacted as described for 2-{[(2-methoxy-ethyl)-methyl-amino]-methyl}-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide in WO03/043636. Usual workup, preparative reversed-phase HPLC and final dry-freezing afforded the tide compound as light yellow solid (48% yield). Mp 108-111° C., MS: m/e=469(M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371748B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-dd83651cf02b4b43b4b46d688eadf00b |
| Source note | uspto-grants-2008_05 |