2-Bromoisonicotinic acid → 2-Bromo-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide

HRID 2222173Notes

Reaction equation

HRID 2222173 reaction equation
[O:1]1[CH2:7][CH:6]([C:8]2[C:16]3[S:15][C:14]([NH2:17])=[N:13][C:12]=3[C:11]([O:18][CH3:19])=[CH:10][CH:9]=2)[CH2:5][O:4][CH2:3][CH2:2]1.[Br:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][N:29]=1)[C:24](O)=[O:25].O1CC(C2C3SC(NC(C4SC(C)=CC=4)=O)=NC=3C(OC)=CC=2)COCC1>>[Br:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][N:29]=1)[C:24]([NH:17][C:14]1[S:15][C:16]2[C:8]([CH:6]3[CH2:5][O:4][CH2:3][CH2:2][O:1][CH2:7]3)=[CH:9][CH:10]=[C:11]([O:18][CH3:19])[C:12]=2[N:13]=1)=[O:25]

Participants

4

Reactant 3

HCID 2227012-Bromoisonicotinic acidHCID 113731005-Methyl-thiophene-2-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amideHCID 597118057-[1,4]Dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine

Product 1

HCID 865951522-Bromo-N-(7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide

Procedure

Using 7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-ylamine and 2-bromo-isonicotinic acid, the title compound was prepared in the same manner as described for 5-methyl-thiophene-2-carboxylic acid (7-[1,4]dioxepan-6-yl-4-methoxy-benzothiazol-2-yl)-amide and obtained as off-white powder. MS: m/e=452(M+H+).

Workup

  1. customobtained as off-white powder

Sources & evidence

ORD record
ord-bf814ad8c0054974b08c222f06eb0790
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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