HCID 11257802, compound → HCID 178488702, compound

HRID 2222174Notes

Reaction equation

HRID 2222174 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.[OH:19][CH:20]1[CH2:25][CH2:24][CH:23]([CH2:26][C:27](O)=[O:28])[CH2:22][CH2:21]1.COC1C2N=C(NC(=O)CC3CCOCC3)SC=2C(C2CCOCC2)=CC=1>>[OH:19][C@H:20]1[CH2:25][CH2:24][C@H:23]([CH2:26][C:27]([NH:12][C:10]2[S:11][C:7]3[C:6]([CH:13]4[CH2:18][CH2:17][O:16][CH2:15][CH2:14]4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:28])[CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 11257802HCID 11257802, compoundHCID 12702257(4-Hydroxycyclohexyl)acetic acidHCID 220157354-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine

Product 1

HCID 178488702HCID 178488702, compound

Procedure

Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine and (4-hydroxy-cyclohexyl)-acetic acid, the title compound was prepared in the same manner as described for N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-2-(tetrahydro-pyran-4-yl)-acetamide and obtained as white crystals (25% yield). Mp 120-145° C., MS: m/e=405(M+H+).

Sources & evidence

ORD record
ord-409ca42caa7e485b80f89ff62d48795e
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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