Tetrahydro-2-furoic acid, (+)- → HCID 86595153, compound

HRID 2222175Notes

Reaction equation

HRID 2222175 reaction equation
COC1C2N=C(N)SC=2C(C2CCOCC2)=CC=1.O1CCC[C@@H]1C(O)=O.[CH3:27][O:28][C:29]1[C:34]2[N:35]=[C:36]([NH:38][C:39](=[O:47])[CH2:40][CH:41]3[CH2:46][CH2:45][O:44]CC3)[S:37][C:33]=2[C:32]([CH:48]2[CH2:53][CH2:52][O:51][CH2:50][CH2:49]2)=[CH:31][CH:30]=1>>[CH3:27][O:28][C:29]1[C:34]2[N:35]=[C:36]([NH:38][C:39]([C@H:40]3[CH2:41][CH2:46][CH2:45][O:44]3)=[O:47])[S:37][C:33]=2[C:32]([CH:48]2[CH2:53][CH2:52][O:51][CH2:50][CH2:49]2)=[CH:31][CH:30]=1

Participants

4

Reactant 3

HCID 2734707Tetrahydro-2-furoic acid, (+)-HCID 11257802HCID 11257802, compoundHCID 220157354-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine

Product 1

HCID 86595153HCID 86595153, compound

Procedure

Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine and (R)-tetrahydro-furan-2-carboxylic acid, the title compound was prepared in the same manner as described for N-[4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl]-2-(tetrahydro-pyran-4-yl)-acetamide and obtained as off-white solid (62% yield). Mp 158-161° C., MS: m/e=363(M+H+).

Sources & evidence

ORD record
ord-8c1ee46cae4a4992aed3aae9777f777d
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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