Phenyl chloroformate → HCID 11177204, compound

HRID 2222176Notes

Reaction equation

HRID 2222176 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1.Cl[C:20](OC1C=CC=CC=1)=[O:21].[OH:29][CH2:30][CH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:20]([N:34]3[CH2:35][CH2:36][CH:31]([CH2:30][OH:29])[CH2:32][CH2:33]3)=[O:21])[S:11][C:7]=2[C:6]([CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 15891Phenyl chloroformateHCID 4207714-PiperidinemethanolHCID 220157354-Methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-yl-amine

Product 1

HCID 11177204HCID 11177204, compound

Procedure

Using 4-methoxy-7-(tetrahydro-pyran-4-yl)-benzothiazol-2-ylamine, phenyl chloroformate and 4-hydroxymethyl-piperidine, the title compound was prepared as white crystals (87% yield). Mp. 202-203.5° C., MS: m/e=406(M+H+).

Sources & evidence

ORD record
ord-882f81af71ec4019b83cfbb75a2c5d53
Source dataset
uspto-grants-2008_05
Patent number
US07371748B2

Reaction notes

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