Hydrogen Bromide → HCID 69287865, compound

Participants

Reaction Steps

A mixture of 2.58 g (7.1 mmol) 2-(4-Chloro-phenylamino)-thiazole-4-carboxylic acid ethyl ester; hydrobromide, 1.87 g (10.7 mmol) 2-Chlorobenzoyl chloride and 2.96 ml (21.4 mmol) NEt3 in 30 ml DCM was stirred at room temperature for 24 h. After evaporation of the volatiles the residue was taken up in MeOH and purified with flash column chromatography on silica eluting with a gradient of heptane/ethyl acetate and to yield after evaporation of the product fractions 2.21 g (74%) of the title compound. MS (m/e): 421.0 (MH+, 100%)

Provenance & Evidence