Water → HCID 69287896, compound

Participants

Reaction Steps

A mixture of 2.74 g (9.3 mmol) 2-(3,4-Dimethoxy-phenylamino)-5-methyl-thiazole-4-carboxylic acid, 1.95 ml (14 mmol) 2,4-Dichlorobenzoyl chloride and 3.88 ml (27.9 mmol) NEt3 in 30 ml DCM was stirred at room temperature for 5 min and 50 ml water was added and the mixture was stirred at room temperature for 16 h. After removal of all volatiles the residue was extracted with DCM and evaporated under reduced pressure to yield 4.18 g of amorphous light brown solid which was used without further purification in the consecutive step. MS (m/e): 467.2 (MH+, 100%)

Provenance & Evidence