HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2222200Generated: October 30, 2026
Bromopyruvic Acid → 2-[[4-(Trifluoromethoxy)phenyl]amino]-4-thiazolecarboxylic acid
https://huagongshe.com/reaction/2222200
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromopyruvic Acid | HCID 70684 | — |
| Reactant | N-[4-(Trifluoromethoxy)phenyl]thiourea | HCID 2777352 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[[4-(Trifluoromethoxy)phenyl]amino]-4-thiazolecarboxylic acid | HCID 33679301 | — |
Reaction Steps
A mixture of 12.9 g (54.6 mmol) [4-(trifluoromethoxy)phenyl]-thiourea, and 9.3 g (55.7 mmol) bromopyruvic acid in 70 ml ethanol was heated to 60° C. for 1 h. The precipitate was filtered off and washed with small portions of cold ethanol to yield after drying 8.9 g (53%) of the title compound as crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07371751B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-3b31233088854821acded695b0937130 |
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| Source note | uspto-grants-2008_05 |
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