HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2222203Generated: October 31, 2026
Potassium Carbonate → HCID 69287841, compound
https://huagongshe.com/reaction/2222203
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,4-Dichlorobenzoyl chloride | HCID 66645 | — |
| Reactant | 2-[[4-(Trifluoromethoxy)phenyl]amino]-4-thiazolecarboxylic acid | HCID 33679301 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 69287841 | HCID 69287841 | 79.4% |
Reaction Steps
A mixture of 2.0 g (6.6 mmol) 2-(4-(trifluoromethoxy)phenylamino)-thiazole-4-carboxylic acid, 3.44 g (16.4 mmol) 2,4-dichloro-benzoyl chloride and 0.92 g (6.6 mmol) potassium carbonate in 50 mL THF was stirred at 50° C. for 48 h. After evaporation of the volatiles the residue was partitioned between water and ethyl acetate. Organic phases were pooled, dried with MgSO4 and the solvent was removed in vacuo. Crystallisation from n-heptane/ethyl acetate yielded 2.5 g (79%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07371751B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-e9bb583d58454507b8b1f3c10f527638 |
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| Source note | uspto-grants-2008_05 |
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