Potassium Carbonate → HCID 69290180, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.0 g (17 mmol) 2-(4-chloro-3-methoxy-phenylamino)-thiazole-4-carboxylic acid, 9.2 g (44 mmol) 2,4-dichloro-benzoyl chloride and 2.45 g (17.7 mmol) potassium carbonate in 250 mL THF was stirred at 50° C. for 18 h. After evaporation of the volatiles the residue was partitioned between water and ethyl acetate. Organic phases were pooled, dried with MgSO4 and the solvent was removed in vacuo. Crystallisation from n-heptane/ethyl acetate yielded 5.8 g (72%) of the title compound.

Provenance & Evidence