HCID 69286939, compound → HCID 11156214, compound

HRID 2222212Notes

Reaction equation

HRID 2222212 reaction equation
[Cl:1][C:2]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:3]=1[C:4]([N:6](C1C=CC(OC)=C(OC)C=1)[C:7]1[S:8][CH:9]=[C:10]([C:12]([OH:14])=O)[N:11]=1)=[O:5].[Cl:30][C:31]1[CH:57]=[CH:56][CH:55]=[CH:54][C:32]=1C(N(C1C=CC(OC)=C(OC)C=1)C1SC=C(C(O)=O)N=1)=O.ClC1C=CC(N(C(=O)C2C=CC(Cl)=CC=2Cl)[C:66]2SC=[C:69]([C:71]([OH:73])=O)[N:70]=2)=CC=1.Cl[C:85]1C=CC=CC=1C(N(C1C=CC(Cl)=CC=1)C1SC=C(C(O)=O)N=1)=O>>[Cl:1][C:2]1[CH:28]=[C:27]([Cl:29])[CH:26]=[CH:25][C:3]=1[C:4]([N:6]([C:55]1[CH:54]=[CH:32][C:31]([Cl:30])=[CH:57][CH:56]=1)[C:7]1[S:8][CH:9]=[C:10]([C:12]([N:70]2[CH2:66][CH2:85][O:73][CH2:71][CH2:69]2)=[O:14])[N:11]=1)=[O:5]

Participants

5

Reactant 4

HCID 69286939HCID 69286939, compoundHCID 69286949HCID 69286949, compoundHCID 69287766HCID 69287766, compoundHCID 69287775HCID 69287775, compound

Product 1

HCID 11156214HCID 11156214, compound

Procedure

According to the procedure described fort he synthesis of Example 4 further derivatives have been synthesised from 2-[(2,4-Dichloro-benzoyl)-(3,4-dimethoxy-phenyl)-amino]-thiazole-4-carboxylic acid, 2-[(2-Chloro-benzoyl)-(3,4-dimethoxy-phenyl)-amino]-thiazole-4-carboxylic acid, 2-[(4-Chloro-phenyl)-(2,4-dichloro-benzoyl)-amino]-thiazole-4-carboxylic acid or 2-[(2-Chloro-benzoyl)-(4-chloro-phenyl)-amino]-thiazole-4-carboxylic acid and various commercially available amines and comprise Examples 5-Example 95 below.

Workup

  1. customfort he synthesis of Example 4 further derivatives

Sources & evidence

ORD record
ord-d461f81a47c04ecea10b9b3366657c72
Source dataset
uspto-grants-2008_05
Patent number
US07371751B2

Reaction notes

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