反应详情

温度

82.5 °C

6-Chloro-1-cyclopropylmethyluracil (24.34 g, 0.12 mol) was suspended in absolute ethanol (245 mL) under nitrogen. Anhydrous hydrazine (11.69 g, 0.36 mol) was added via syringe in excess, resulting in a clear-yellow solution. The reaction mixture was heated at 80-85° C. for one hour; bright yellow crystals began forming within minutes of the application of heat. The reaction mixture was cooled to room temperature and then in an ice bath, and the crude product collected by filtration. N2H4×HCl was removed by triturating with cold water to give the product as a pale yellow solid, 20.47 g (86%). Mp 221° C. (dec).

1. customresulting in a clear-yellow solution
2. custombright yellow crystals began forming within minutes of the application
3. temperatureof heat
4. temperatureThe reaction mixture was cooled to room temperature
5. filtrationin an ice bath, and the crude product collected by filtration
6. customN2H4×HCl was removed
7. customby triturating with cold water