HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2222232Generated: October 25, 2026
Phosphorus sulfide (P2S5) → 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-6-oxo-4-thioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-pyrrole-3-carbonitrile
https://huagongshe.com/reaction/2222232
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | 5-{2-[(6-chloroquinolin-4-yl)methyl]-7-cyclopropylmethyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl}-1-methyl-1H-pyrrole-3-carbonitrile | HCID 17990179 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-6-oxo-4-thioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-pyrrole-3-carbonitrile | HCID 10028991 | — |
Reaction Steps
To a solution of 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3yl]-1methyl-1H-pyrrole-3-carbonitrile (0.53 g) in pyridine (5 mL) was added P4S10 (0.52 g). The mixture was heated by microwave at 140° C. for 100 minutes. The mixture was diluted with water and ethyl acetate. The organic solution was collected, washed with saturated NaHCO3 and brine, dried (Na2SO4), filtered and concentrated. The residue was purified by flash chromatography using a FlashMaster™ yielding 0.44 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07371757B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-2b15afb7c6d948c6a98bb86d04331b1c |
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| Source note | uspto-grants-2008_05 |
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