Acetonitrile → HCID 11409618, compound

Participants

Reaction Steps

To a solution of 5-[2-[(6-chloroquinolinyl)methyl]-7-(cyclopropylmethyl)-6-oxo-4-thioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl- 1H-pyrrole-3-carbonitrile (0.14 g) in acetonitrile (5 mL) and formic hydrazide (80 mg) was added mercury(II) chloride (160 mg). After stirring overnight at rt, the reaction was warmed (Tb=70 C). After 5 h with heat, the reaction was filtered through a celite bed and concentrated. The residue was purified by flash chromatography using a FlashMaster™ yielding 44 mg, 1H NMR (300 MHz, CHLOROFORM-D) d ppm 0.57 (m, 4H) 1.48 (m, J=10.93 Hz, 1H) 3.45 (s, 3H) 4.15 (t, J=6.59 Hz, 2H) 5.86 (m, 2H) 6.68 (d, J=1.70 Hz, 1H) 6.83 (d, J=4.52 Hz, 1H) 7.40 (d, J=1.70 Hz, 1H) 7.72 (dd, J=8.95, 2.17 Hz, 1H) 7.88 (d, J=2.07 Hz, 1H) 8.13 (d, J=8.85 Hz, 1H) 8.84 (d, J=4.33 Hz, 1H) 8.93 (s, 1H);

Provenance & Evidence