Cyanogen Bromide → HCID 11504622, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-[2-[(6-chloroquinolin-4-yl)methyl]-7-(cyclopropylmethyl)-4-hydrazino-6-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-pyrrole-3-carbonitrile (0.13 g) in dioxane (3 mL) was added cyanogen bromide (0.15 mL). The reaction was heated by microwave at 100° C. for 5 min. The mixture was concentrated and purified by HPLC yielding 27 mg of yellow foam, 1H NMR (300 MHz, CHLOROFORM-D) d ppm 0.56 (m, 4 H) 1.44 (m, 1H) 3.7 (s, 3H) 3.94 (m, 2H) 5.84 (m, 2H) 6.54 (d, 1H) 6.86 (m, 1H) 7.71 (m, 2H) 7.87 (m, 1H) 8.12 (m, 1H) 8.85 (m, 1H); ES M+H+=525.

Provenance & Evidence