Potassium Iodide → 5-[2-[4-(1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]ethyl]-2-methylthio-3,6-dimethyl-3H-pyrimidin-4-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(1,2,3,6-tetrahydropyridin-4-yl)indole (1.0 g, 5 mmol) in acetonitrile (30 ml) was added 2-methylthio-5-(2-chloroethyl)-3,6-dimethyl-3H-pyrimidin-4-one (1.42 g, 6.1 mmol), potassium iodide (0.84 g, 5 mmol) and triethylamine (1.4 ml, 10 mmol). The mixture was heated at 80° C. for 8 hours, cooled, concentrated and purified by flash chromatografy (dichloromethane/methanol/ammonia=95/4.5/0.5)

Provenance & Evidence