HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylbutyrolactone → HCID 136347822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylbutyrolactone | HCID 10601 | — |
| Reactant | Carbamimidic acid, methyl ester, sulfate (1:1) | HCID 169039 | — |
| Reactant | Calcium Hydroxide | HCID 6093208 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 136347822 | HCID 136347822 | — |
Reaction Steps
To a solution of O-methylisourea hydrogen sulfate (17.2 g, 0.1 mol) in water (90 ml) was added calcium hydroxide (8.14 g, 0.11 mol) followed by a solution of 2-acetylbutyrolactone (10.7 ml, 0.1 mol) in ethanol (70 ml). The mixture was stirred at room temperature for two days, filtered and washed with ethanol. The filtrate was concentrated in vaccuum and purified by flash chromatografy (dichloromethane/methanol=95/5). Yield 2.6 g (14%) of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371769B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-4bed4e2ca65440469c8fdc042a619c3f |
| Source note | uspto-grants-2008_05 |