反应详情

Ethyl 2-(6-quinolinyloxy)-2-(ethoxy)acetate (3.68 g) was added to a solution of sodium hydroxide (0.589 g) in water (10 ml) and methanol (30 ml) and stirred for 5 minutes. The solution was evaporated under reduced pressure, water added and the aqueous phase was washed with ethyl acetate. The aqueous phase was acidified with hydrochloric acid and extracted with ethyl acetate. The extracts were combined, dried over magnesium sulphate and evaporated under reduced pressure to give 2-(6-quinolinyloxy)-2-(ethoxy)acetic acid (1.47 g) as a cream solid.

1. customThe solution was evaporated under reduced pressure, water
2. additionadded
3. washthe aqueous phase was washed with ethyl acetate
4. extractionextracted with ethyl acetate
5. dry with materialdried over magnesium sulphate
6. customevaporated under reduced pressure