HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Isoquinolinol → 2-(7-isoquinolinyloxy)-N-(2-methylpent-3-yn-2-yl)-3-methoxypropionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Isoquinolinol | HCID 459767 | — |
| Reactant | 2-bromo-3-methoxy-N-(4-methylpent-2-yn-4-yl)propionamide | HCID 21078405 | — |
| Product | 2-(7-isoquinolinyloxy)-N-(2-methylpent-3-yn-2-yl)-3-methoxypropionamide | HCID 21923115 | — |
Reaction Steps
In a similar procedure to Example 6, 7-hydroxyisoquinoline (commercially available) and 2-bromo-N-(4-methylpent-2-yn-4-yl) 3-methoxypropionamide were reacted to give 2-(7-isoquinolinyloxy)-N-(2-methylpent-3-yn-2-yl)-3-methoxypropionamide (Compound No. 2 of Table 49) as a colourless solid, m.p. 155-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07371764B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-7896302eb0be4b07858a8d15dc6daf74 |
| Source note | uspto-grants-2008_05 |