3-Bromoquinolin-6-ol → 2-(3-bromo-6-quinolinyloxy)-N-(1-chloro-6-methylhept-4-yn-6-yl) butyramide

Participants

Reaction Steps

In a similar procedure to Example 6 Stage 2, 3-bromo-6-hydroxyquinoline was reacted with 2-bromo-N-(1-chloro-6-methylhept-4-yn-6-yl) butyramide to give 2-(3-bromo-6-quinolinyloxy)-N-(1-chloro-6-methylhept-4-yn-6-yl) butyramide as a colourless oil. 1H NMR (CDCl3) δ: 1.04-1.10(3H, t); 1.60(6H, s); 1.86-1.94(2H, m); 2.00-2.06(2H, m); 2.32-2.36(2H, t); 3.60-3.64(2H, t); 4.56(1H, t); 6.34(1H, s); 7.02 (1H, m); 7.42-7.46(1H, dd); 8.03 (1H, d); 8.22(1H, s); 8.78(1H, s).

Provenance & Evidence