3,4-Dimethoxybenzeneacetonitrile → HCID 6212251, compound

HRID 2222341Notes

Reaction equation

HRID 2222341 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=1[O:21][CH3:22])[CH2:15][C:16]#[N:17]>>[CH3:10][O:11][C:12]1[CH:13]=[C:14](/[C:15](=[CH:4]/[C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[F:1])/[C:16]#[N:17])[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 67970o-Fluorobenzaldehyde

Product 1

HCID 6212251HCID 6212251, compoundYield 40%

Procedure

2-Fluorobenzaldehyde (620 mg) and 3,4-dimethoxybenzyl cyanide (880 mg) were subjected to condensation in accordance with process A of (production process 2), to thereby produce the target product (562 mg, yield: 40%).

Sources & evidence

ORD record
ord-c3895d2c3a6f4c678c52b90bf3ebe5b3
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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