3,4-Dimethoxybenzeneacetonitrile → HCID 11722375, compound

HRID 2222345Notes

Reaction equation

HRID 2222345 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH:4]=O.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH2:16][C:17]#[N:18]>>[F:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1/[CH:4]=[C:16](/[C:15]1[CH:19]=[CH:20][C:21]([O:22][CH3:23])=[C:13]([O:12][CH3:11])[CH:14]=1)\[C:17]#[N:18]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 1376632,5-Difluorobenzaldehyde

Product 1

HCID 11722375HCID 11722375, compoundYield 73.1%

Procedure

2,5-Difluorobenzaldehyde (1.42 g) and 3,4-dimethoxybenzyl cyanide (1.77 g) were subjected to condensation in accordance with process A of (production process 2), to thereby produce the target product (2.20 g, yield: 73%).

Sources & evidence

ORD record
ord-cc1177837e764b67b75a43fdd05b5343
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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