3,4-Dimethoxybenzeneacetonitrile → HCID 10040509, compound

HRID 2222346Notes

Reaction equation

HRID 2222346 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH2:16][C:17]#[N:18]>>[F:1][C:2]1[CH:3]=[C:4](/[CH:5]=[C:16](/[C:15]2[CH:19]=[CH:20][C:21]([O:22][CH3:23])=[C:13]([O:12][CH3:11])[CH:14]=2)\[C:17]#[N:18])[CH:7]=[CH:8][C:9]=1[F:10]

Participants

3

Reactant 2

HCID 667273,4-DimethoxybenzeneacetonitrileHCID 5880883,4-Difluorobenzaldehyde

Product 1

HCID 10040509HCID 10040509, compoundYield 86.4%

Procedure

3,4-Difluorobenzaldehyde (426 mg) and 3,4-dimethoxybenzyl cyanide (532 mg) were subjected to condensation in accordance with process A of (production process 2), to thereby produce the target product (780 mg, yield: 86%).

Sources & evidence

ORD record
ord-014f0699ecb345c2b661219158fba69a
Source dataset
uspto-grants-2008_05
Patent number
US07371773B2

Reaction notes

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